Cortisone acetate

Research use only, not for human use.

Cortisone acetate (Cortisone 21-acetate) is a synthetic glucocorticoid corticosteroid and corticosteroid ester.

Cortisone acetate (Cortisone 21-acetate) is a synthetic glucocorticoid corticosteroid and corticosteroid ester; the C21 acetate ester of cortisone and acts as a prodrug of cortisone in the body.Allergy Approved(In Vitro):Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).(In Vivo):Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits.

Cortisone (2.8-28,000 nM) dose-dependently attenuates the apoptosis induced by Cortisol in peripheral-blood mononuclear cells (PBMCs).

Cortisone (2 mg/kg; i.m. on alternate days for 2 months) decreases the BCG (the vaccine strain of tubercle bacillus) lesions and tuberculin reactions in rabbits. Animal Model:Male New Zealand white rabbits (2.1-2.4 kg) were injected with BCG at six days after the first administrtion Dosage:2 mg/kg Administration:Intramuscular injection on alternate days for 2 months Result:Reduced the BCG lesions and tuberculin reactions.Reduced the number of infiltrating mononuclear cells (MN), the amount of caseous necrosis and ulceration, and the percent of NM that were beta-galactosidase-positive.

Cortisone 21-acetate

Endocrinology/Hormones

GR

GlucocorticoidReceptor

Inflammation/Immunology

Allergy

50-04-4

402.4807

C23H30O6

>98% (HPLC)

DMSO: 6.8 mg/mL (Need ultrasonic and warming)

CC(=O)OCC(=O)[C@]1(CC[C@@H]2[C@@]1(CC(=O)[C@H]3[C@H]2CCC4=CC(=O)CC[C@]34C)C)O

Pregn-4-ene-3,11,20-trione, 21-(acetyloxy)-17-hydroxy- (9CI)

(-20℃)

With Ice Pack

≥ 2 years